Enhanced vertical alveolar bone augmentation by recombinant human bone morphogenetic protein-2 with a carrier in rats.
Identifieur interne : 006C93 ( Main/Exploration ); précédent : 006C92; suivant : 006C94Enhanced vertical alveolar bone augmentation by recombinant human bone morphogenetic protein-2 with a carrier in rats.
Auteurs : C. Shimazu [Japon] ; T. Hara ; Y. Kinuta ; K. Moriya ; Y. Maruo ; S. Hanada ; S. MinagiSource :
- Journal of oral rehabilitation [ 0305-182X ] ; 2006.
Descripteurs français
- KwdFr :
- Acide lactique, Acide polyglycolique, Animaux, Facteur de croissance transformant bêta (usage thérapeutique), Matériaux biocompatibles, Microscopie électronique, Mâchoire édentée (anatomopathologie), Mâchoire édentée (physiopathologie), Mâle, Ostéoblastes (anatomopathologie), Polymères, Processus alvéolaire (anatomopathologie), Processus alvéolaire (physiopathologie), Protéine morphogénétique osseuse de type 2, Protéines morphogénétiques osseuses (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Rat Wistar, Rats, Reconstruction de crête alvéolaire (), Régénération osseuse (), Substituts osseux (usage thérapeutique), Éponge de gélatine résorbable.
- MESH :
- anatomopathologie : Mâchoire édentée, Ostéoblastes, Processus alvéolaire.
- physiopathologie : Mâchoire édentée, Processus alvéolaire.
- usage thérapeutique : Facteur de croissance transformant bêta, Protéines morphogénétiques osseuses, Protéines recombinantes, Substituts osseux.
- Acide lactique, Acide polyglycolique, Animaux, Matériaux biocompatibles, Microscopie électronique, Mâle, Polymères, Protéine morphogénétique osseuse de type 2, Rat Wistar, Rats, Reconstruction de crête alvéolaire, Régénération osseuse, Éponge de gélatine résorbable.
English descriptors
- KwdEn :
- Alveolar Process (pathology), Alveolar Process (physiopathology), Alveolar Ridge Augmentation (methods), Animals, Biocompatible Materials, Bone Morphogenetic Protein 2, Bone Morphogenetic Proteins (therapeutic use), Bone Regeneration (drug effects), Bone Substitutes (therapeutic use), Gelatin Sponge, Absorbable, Jaw, Edentulous (pathology), Jaw, Edentulous (physiopathology), Lactic Acid, Male, Microscopy, Electron, Osteoblasts (pathology), Polyglycolic Acid, Polymers, Rats, Rats, Wistar, Recombinant Proteins (therapeutic use), Transforming Growth Factor beta (therapeutic use).
- MESH :
- chemical , therapeutic use : Bone Morphogenetic Proteins, Bone Substitutes, Recombinant Proteins, Transforming Growth Factor beta.
- chemical : Biocompatible Materials, Bone Morphogenetic Protein 2, Lactic Acid, Polyglycolic Acid, Polymers.
- drug effects : Bone Regeneration.
- methods : Alveolar Ridge Augmentation.
- pathology : Alveolar Process, Jaw, Edentulous, Osteoblasts.
- physiopathology : Alveolar Process, Jaw, Edentulous.
- Animals, Gelatin Sponge, Absorbable, Male, Microscopy, Electron, Rats, Rats, Wistar.
Abstract
This study aimed to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on vertical bone regeneration of edentulous ridge. Bilateral upper first and second molars of 8-week-old Wistar rats were extracted and the ridges were allowed to heal for 3 weeks. Compressed poly(lactic-co-glycolic acid) copolymer/gelatin sponge (PGS) was used as a carrier of rhBMP-2. PGS alone (control group) or PGS with 5 mug rhBMP-2 (test group) was implanted at the top part of alveolar ridge. The sham group received no implantation. The rats were killed at 1, 2, 4, 8 and 12 weeks after implantation and examined histologically and histomorphometrically. In the test group, significant bone augmentation was evident on the alveolar ridge throughout the experimental period. Histomorphometric analysis revealed greater tissue volume and height of alveolar bone in the test group compared with the control and sham groups (P < 0.05) from 4 weeks onward and the augmented tissues (5 mm3 in tissue volume and 1.5 mm in bone height) were maintained until 12 weeks. Osteoblast surface increased at 2 and 4 weeks and osteoid thickness reached a peak (25 microm) at 2 weeks. Dynamic variables, which represented calcification, were higher in the test group than the control and sham groups at 4 and 8 weeks (P < 0.05). These results suggest that use of rhBMP-2/PGS may achieve vertical bone augmentation, and stabilizes denture prosthesis or makes up for inadequate bone mass for implant prosthesis.
DOI: 10.1111/j.1365-2842.2005.01593.x
PubMed: 16856959
Affiliations:
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Le document en format XML
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Kinuta</name></author><author><name sortKey="Moriya, K" sort="Moriya, K" uniqKey="Moriya K" first="K" last="Moriya">K. Moriya</name></author><author><name sortKey="Maruo, Y" sort="Maruo, Y" uniqKey="Maruo Y" first="Y" last="Maruo">Y. Maruo</name></author><author><name sortKey="Hanada, S" sort="Hanada, S" uniqKey="Hanada S" first="S" last="Hanada">S. Hanada</name></author><author><name sortKey="Minagi, S" sort="Minagi, S" uniqKey="Minagi S" first="S" last="Minagi">S. 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Shimazu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine and Dentistry, Okayama City</wicri:regionArea><wicri:noRegion>Okayama City</wicri:noRegion></affiliation></author><author><name sortKey="Hara, T" sort="Hara, T" uniqKey="Hara T" first="T" last="Hara">T. Hara</name></author><author><name sortKey="Kinuta, Y" sort="Kinuta, Y" uniqKey="Kinuta Y" first="Y" last="Kinuta">Y. Kinuta</name></author><author><name sortKey="Moriya, K" sort="Moriya, K" uniqKey="Moriya K" first="K" last="Moriya">K. Moriya</name></author><author><name sortKey="Maruo, Y" sort="Maruo, Y" uniqKey="Maruo Y" first="Y" last="Maruo">Y. Maruo</name></author><author><name sortKey="Hanada, S" sort="Hanada, S" uniqKey="Hanada S" first="S" last="Hanada">S. Hanada</name></author><author><name sortKey="Minagi, S" sort="Minagi, S" uniqKey="Minagi S" first="S" last="Minagi">S. Minagi</name></author></analytic><series><title level="j">Journal of oral rehabilitation</title><idno type="ISSN">0305-182X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Process (pathology)</term><term>Alveolar Process (physiopathology)</term><term>Alveolar Ridge Augmentation (methods)</term><term>Animals</term><term>Biocompatible Materials</term><term>Bone Morphogenetic Protein 2</term><term>Bone Morphogenetic Proteins (therapeutic use)</term><term>Bone Regeneration (drug effects)</term><term>Bone Substitutes (therapeutic use)</term><term>Gelatin Sponge, Absorbable</term><term>Jaw, Edentulous (pathology)</term><term>Jaw, Edentulous (physiopathology)</term><term>Lactic Acid</term><term>Male</term><term>Microscopy, Electron</term><term>Osteoblasts (pathology)</term><term>Polyglycolic Acid</term><term>Polymers</term><term>Rats</term><term>Rats, Wistar</term><term>Recombinant Proteins (therapeutic use)</term><term>Transforming Growth Factor beta (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide lactique</term><term>Acide polyglycolique</term><term>Animaux</term><term>Facteur de croissance transformant bêta (usage thérapeutique)</term><term>Matériaux biocompatibles</term><term>Microscopie électronique</term><term>Mâchoire édentée (anatomopathologie)</term><term>Mâchoire édentée (physiopathologie)</term><term>Mâle</term><term>Ostéoblastes (anatomopathologie)</term><term>Polymères</term><term>Processus alvéolaire (anatomopathologie)</term><term>Processus alvéolaire (physiopathologie)</term><term>Protéine morphogénétique osseuse de type 2</term><term>Protéines morphogénétiques osseuses (usage thérapeutique)</term><term>Protéines recombinantes (usage thérapeutique)</term><term>Rat Wistar</term><term>Rats</term><term>Reconstruction de crête alvéolaire ()</term><term>Régénération osseuse ()</term><term>Substituts osseux (usage thérapeutique)</term><term>Éponge de gélatine résorbable</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Morphogenetic Proteins</term><term>Bone Substitutes</term><term>Recombinant Proteins</term><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biocompatible Materials</term><term>Bone Morphogenetic Protein 2</term><term>Lactic Acid</term><term>Polyglycolic Acid</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mâchoire édentée</term><term>Ostéoblastes</term><term>Processus alvéolaire</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bone Regeneration</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term><term>Jaw, Edentulous</term><term>Osteoblasts</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Mâchoire édentée</term><term>Processus alvéolaire</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alveolar Process</term><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance transformant bêta</term><term>Protéines morphogénétiques osseuses</term><term>Protéines recombinantes</term><term>Substituts osseux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gelatin Sponge, Absorbable</term><term>Male</term><term>Microscopy, Electron</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide lactique</term><term>Acide polyglycolique</term><term>Animaux</term><term>Matériaux biocompatibles</term><term>Microscopie électronique</term><term>Mâle</term><term>Polymères</term><term>Protéine morphogénétique osseuse de type 2</term><term>Rat Wistar</term><term>Rats</term><term>Reconstruction de crête alvéolaire</term><term>Régénération osseuse</term><term>Éponge de gélatine résorbable</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aimed to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on vertical bone regeneration of edentulous ridge. Bilateral upper first and second molars of 8-week-old Wistar rats were extracted and the ridges were allowed to heal for 3 weeks. Compressed poly(lactic-co-glycolic acid) copolymer/gelatin sponge (PGS) was used as a carrier of rhBMP-2. PGS alone (control group) or PGS with 5 mug rhBMP-2 (test group) was implanted at the top part of alveolar ridge. The sham group received no implantation. The rats were killed at 1, 2, 4, 8 and 12 weeks after implantation and examined histologically and histomorphometrically. In the test group, significant bone augmentation was evident on the alveolar ridge throughout the experimental period. Histomorphometric analysis revealed greater tissue volume and height of alveolar bone in the test group compared with the control and sham groups (P < 0.05) from 4 weeks onward and the augmented tissues (5 mm3 in tissue volume and 1.5 mm in bone height) were maintained until 12 weeks. Osteoblast surface increased at 2 and 4 weeks and osteoid thickness reached a peak (25 microm) at 2 weeks. Dynamic variables, which represented calcification, were higher in the test group than the control and sham groups at 4 and 8 weeks (P < 0.05). These results suggest that use of rhBMP-2/PGS may achieve vertical bone augmentation, and stabilizes denture prosthesis or makes up for inadequate bone mass for implant prosthesis.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Hanada, S" sort="Hanada, S" uniqKey="Hanada S" first="S" last="Hanada">S. Hanada</name><name sortKey="Hara, T" sort="Hara, T" uniqKey="Hara T" first="T" last="Hara">T. Hara</name><name sortKey="Kinuta, Y" sort="Kinuta, Y" uniqKey="Kinuta Y" first="Y" last="Kinuta">Y. Kinuta</name><name sortKey="Maruo, Y" sort="Maruo, Y" uniqKey="Maruo Y" first="Y" last="Maruo">Y. Maruo</name><name sortKey="Minagi, S" sort="Minagi, S" uniqKey="Minagi S" first="S" last="Minagi">S. Minagi</name><name sortKey="Moriya, K" sort="Moriya, K" uniqKey="Moriya K" first="K" last="Moriya">K. Moriya</name></noCountry><country name="Japon"><noRegion><name sortKey="Shimazu, C" sort="Shimazu, C" uniqKey="Shimazu C" first="C" last="Shimazu">C. Shimazu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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